Ethamsylate
It exerts haemostatic action by acting on the first step of haemostasis by improving platelet adhesiveness and restoring capillary resistance. It decreases bleeding time and increases platelet aggregation. It reduces capillary bleeding when platelets are adequate. The drug exerts antihyaluronidase action and improves capillary wall stability. It inhibits PGI-2 synthesis and correct abnormal platelet function.
Tranexamic Acid
Tranexamic acid exerts antifibrinolytic effect by forming a reversible complex with plasminogen through the lysine binding site of fibrin and thus displaces the plasminogen from the fibrin surface ; preventing the binding of plasmin to fibrinogen or fibrin monomers. It inhibits the activation of plasminogen (i.e. formation of plasmin). It also acts as a weak non competitive inhibitor of plasmin and blocks it`s action on fibrin.
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Ethamsylate
1. Headache
2. Nausea
3. Rash
4. Fall in BP(only after I.V. administration)
Tranexamic Acid
1.Nausea
2.Diarrhoea
3.Gastrointestinal problems
4.Headache
5.Hypotension
6.Giddiness
7.Thrombophlebitis at injected vein
8.Impairment of Colour vision
Ethamsylate
Absorption: Well absorbed orally.
Distribution: Distributed in a protein bound form.
Excretion: Excreted through urine as unchanged drug.
Tranexamic Acid
Absorption: About 40% is absorbed orally. Distribution: Widely distributed in the body. Excretion: Excreted mainly as unchanged drug.
Important Notice:- The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
Ferrous Ascorbate 100 mg Folic Acid 1.5 mg Zinc 61.8 mg Tablet