Thiocolchicoside 8 mg Capsule
Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside with a relaxant effect on skeletal muscle, has been found to displace both [3H]gamma-amino butyric acid ([3H]GABA) and [3H]strychnine binding, suggesting an interaction with both GABA and strychnine-sensitive glycine receptors.
Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside and is a muscle relaxant agent with anti-inflammatory and analgesic actions, also is used topically for the treatment of muscular spasms and for rheumatologic, orthopedic, and traumatologic disorders and has been found to displace both [3H] gamma-amino butyric acid ([3H] GABA) and [3H] strychnine binding, suggesting an interaction with both GABA and strychnine-sensitive glycine receptors.
MK Medicine is a leading pcd franchise provider, contract manufacturer and hospital supplier of WHO-GMP certified Thiocolchicoside 8 mg Capsule
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The most common adverse reactions were somnolence, nasopharyngitis, fatigue, dry mouth and pharyngitis, and most were mild to moderate in intensity.
This compound has been shown to inhibit the binding of [3H] GABA (g-amino butyric acid) or [3H] strychnine of cerebrocortical or spinal cord membranes. [3H]TCC was also displaced in a concentration-dependent manner by GABA or by several agonists or antagonists of the type A receptor for GABA (GABAAR). TCC has been thought to act as a GABAAR agonist that induces depression of the central nervous system and, in turn, myorelaxation. Moreover, TCC possesses a molecular structure similar to that of colchicine, a plant alkaloid that binds to tubulin and induces the depolymerization of microtubules, disrupts axonal transport, and inhibits mitosis. Following oral administration, thiocolchicoside is well absorbed from the gastrointestinal tract. It shows its effect in 1-2 hours after oral administration and peak plasma level is achieved in about 0.7 hours and Elimination half-life is about 2.5-5 hours. Its effect is continued for 24 hours.
- Interaction with alcohol is unknown. Please consult your doctor.
- May be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor. - No information is available on the use of Thiocolchicoside Capsule during lactation. Please consult your doctor.
- Thiocolchicoside Capsule may cause side effects which could affect your ability to drive.
Important Notice:- The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
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