Paracetamol 125 mg, Mefenamic Acid 50mg Syrup
Mefenamic acid plus paracetamol suspension is a highly useful combination for the treatment of moderate. Pains connected with rheumatoid arthritis. Paracetarnol is one of the most popular non-prescriptive analgesics, antipyretic drug. Mefenamic acid is a non-steroidal anti-inflammatory agent with analgesic properties, and a demonstrable antipyretic effect. It is licensed as an anti-inflammatory analgesic for the symptomatic relief of rheumatoid arthritis, osteoarthritis and pain including muscular, dental pain, headaches and pyrexia in children. The medicine is available in oral suspension formulation for the paediatrics population.
MK Medicine is a leading pcd franchise provider, contract manufacturer and hospital supplier of WHO-GMP certified Paracetamol 125 mg, Mefenamic Acid 50mg Syrup
60 ml
The most commonly reported adverse effects are:
- Feeling or being sick
- Hypersensitivity reactions
- Skin rashes
- Diarrhea
- Nausea
Mefenamic Acid:
- Absorption: oral absorption of mefenamic acid is found to be 92.5%.
- Distribution: volume of distribution is found to be 1.3 l/kg and plasma protein binding is 99%.
- Metabolism: metabolism is reported Hepatic via enzyme CYP2C9.
- Excretion: renal excretion accounts for 70% and plasma half life is 3-4 hr.
Paracetamol:
- Absorption: oral absorbed from the gastrointestinal tract ranging from 70 to 90%. Paracetamol is also well absorbed from the rectum.
- Distribution: It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells.
- Metabolism: Paracetamol is extensively metabolized (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
- Excretion: A minor fraction of drug is converted to a highly reactive alkylating metabolite and excreted in the urine as cysteine and mercapturic acid conjugates.
Important Notice:- The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
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