Phenylepherine HCL 2.5 mg Chlorpheniramine Maleate 2 mg Paracetamol 125 mg Syrup
This medicine is used for the relief of clogged nose, runny nose, postnasal drip, itchy and watery eyes, sneezing, headache, body aches and fever associated with the common cold, allergic rhinitis, sinusitis, flu and other minor respiratory tract infections. It also helps decongest sinus openings and passages.
For the temporary relief of:
- Headache
- Sinus congestion and pressure
- Nasal congestion
- Runny nose and sneezing
- Minor aches and pains
- Reduces swelling of nasal passages
- Helps decongest sinus openings and passages
MK Medicine is a leading pcd franchise provider, contract manufacturer and hospital supplier of WHO-GMP certified Phenylepherine HCL 2.5 mg Chlorpheniramine Maleate 2 mg Paracetamol 125 mg Syrup
100 ml
The following class of drugs if co-administered with the medication may cause severe drug interactions:-
Anti-depressants, sympathomimetic agents(epinephrine), Anesthetics(halothane), adrenergic-blocking agent (e.g., Phenothiazine drugs) and any other drug containing paracetamol.
Paracetamol has low incidences of side effects. Skin rash and minor stomach and intestinal disturbances may occur.
Cholrpheniramine Maleate may cause sleepiness and drowsiness.
Phenylephrine HCL may cause tremor, restlessness or anxiety.
Paracetamol is an effective analgesic-antipyretic (relieves mild to moderate pain) and a weak anti-inflammatory agent.
Absorption: It is readily absorbed from the g.i. tract with peak plasma concentrations occurring about 10 to 60 min. after oral administration.
Distribution: It is distributed into most body tissues.
Elimination: Approximately 80% of acetaminophen is excreted in the urine after conjugation and about 3% is excreted unchanged.
Half life: 1 to 4 hours.
Chlorpheniramine Maleate is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. Chlorpheniramine binds to the histamine H1 receptor. This block the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Absorption: Well absorbed in the gastrointestinal tract.
Protein binding: 72%.
Metabolism: Primarily hepatic via Cytochrome P450 (CYP450) enzymes.
Half life: 21-27 hours.
Phenylephrine Hydrochloride is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells.
Absorption: Completely absorbed after oral administration. Peak serum concentrations are achieved approximately 0.75-2 hours following oral administration.
Protein binding: 95% binding-plasma proteins.
Metabolism: Undergoes extensive first-pass metabolism in the intestinal wall and extensive metabolism in the liver.
Route of elimination: Phenylephrine and its metabolites are mainly excreted in urine.
Half life: 2.1 to 3.4 hours.
Avoid alcoholic drinks during the usage of this medication.
Important Notice:- The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
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