Aceclofenac 100 mg Paracetamol 325 mg Tablet
Aceclofenac is a non-steroidal anti-inflammatory drug used for the treatment of pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis (a type of arthritis affecting the spine).
Paracetamol also known as Acetaminophen, is commonly used for its analgesic and antipyretic effects for temporary relief of fever, minor aches, and pains.
Indications
Anti-inflammatory, antipyretic agents used to treat pain and swelling.
Rationale of Combination
The combination medication is used to treat pain and inflammation. It is and excellent pain reliever and anti-inflammatory analgesic medicine. Its is used in the treatment of chronic pains. Aceclofenac has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity which are overcomed with the combination of aceclofenac, thereby enhancing the overall efficacy of the product as a whole.
MK Medicine is a leading pcd franchise provider, contract manufacturer and hospital supplier of WHO-GMP certified Aceclofenac 100 mg Paracetamol 325 mg Tablet
10x10 (Alu-Alu / Blister)
Contraindicated in patients with severe ulcer, gastrointestinal bleeding, and hypersensitivity.
Paracetamol causes nausea, allergic reactions, skin rashes, acute renal tubular necrosis. Whereas the underlined side effects of Aceclofenac are diarrhoea, headache, vertigo, dizzies, nervousness, tinnitus, depression, drowsiness, insomnia, fever, angioedema, bronchospasm, rashes, blooddyscrasias.
Oral
Disclaimer:To be taken only after consulting with the doctor.
Aceclofenac
Aceclofenac is a non steroidal anti inflammatory agent which inhibits prostaglandin synthesis by inhibiting the enzyme cyclooxygenase.Aceclofenac is rapidly and completely absorbed after oral administration, peak plasma concentrations are reached 1 to 3 hours after an oral dose. The presence of food does alter the extent of absorption of aceclofenac but the absorption rate is reduced. The drug is highly protein bound (7.99%). Renal excretion is the main route of elimination of aceclofenac with 70 to 80% of an administered dose found in the urine.
Paracetamol
Paracetamol is a widely used analgesic and antipyretic agent. Paracetamol is well absorbed in gastro intestinal tract. Oral bioavailability is dose dependant since the half life of Paracetamol is 1-3hrs. Paracetamol is distributed throughout the body fluids in a homogeneous way. Paracetamol given at therapeutic doses binds to plasma proteins at less than 20%Metabolites are excreted through the kidneys in the urine.
Paracetamol reduces the absorption of cholestyramine within 1 hour of administration whereas it accelerates the absorption with metoclopramide. Aceclofenac may increase the plasma concentrations of lithium and digoxin and induces increased nephrotoxicity with diuretics. Serum-potassium should be monitored when used with potassium-sparing diuretics. Aceclofenac may enhance activity of anticoagulants and also increase plasma methotrexate levels leading to toxicity if administered within 2-4 hours of methotrexate admin. It bears the risk of convulsions with quinolones.
Potentially Fatal: Paracetamol causes increased risk of liver damage in chronic alcoholics along with an increased risk of toxicity with high doses or long term administration of barbiturates, carbamazepine, hydantoins, isoniazid, rifampin and sulfinpyrazone.
Important Notice:- The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
Aceclofenac 200 mg Sustained Release Tablet