Etoricoxib 60 mg Thiocolchicoside 4 mg tablet
It is used medically to treat orthopedic, traumatological and rheumatologic disorders as well as to treat muscular spasms. It is also used to control the pain and swelling suffered by individuals with four medical conditions:
Rheumatoid arthritis : Rheumatoid arthritis is a disorder in which joint cartilage becomes inflamed and, over time destroyed.
Gout : Gout is a condition in which uric acid crystals accumulate within the cartilage of joints, resulting in extreme pain and inflammation.
Osteoarthritis : Osteoarthritis concerns the gradual and irreversible degradation of the cartilage located within bone joints.
Ankylosing spondylitis : In this disorder, the joints between the vertebrae in the spinal column come under attack by the immune system, and cause inflammation.
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10x10 (Alu-Alu) / (Blister)
Allergic disorders, coagulation defects; history of cardiac failure, left Ventricular dysfunction, hypertension, or in patients with oedema due to other Reasons; elderly, renal, cardiac or hepatic impairment.
GI Disorders; Ischemic Cardiac Events; Hypersensitivity Reactions, Headache, Dizziness, Nervousness, Depression, Drowsiness, Insomnia, Vertigo, Tinnitus, Photosensitivity; Blood Disorders, Fluid Retention, Hypertension; Dry Mouth, Taste Disturbance, Mouth Ulcers; Appetite And Wt Changes; Chest Pain, Fatigue, Paraesthesia, Influenza-Like Syndrome, Myalgia. Renal Toxicity.
Etoricoxib selectively inhibits cyclooxygenase 2 (COX-2).
| Bioavailability | 100% |
| Protein binding | 92% |
| Metabolism | Hepatic, CYP extensively involved (mainly CYP3A4) |
| Half-life | 22 hours |
| Excretion | Renal (70%) and fecal (20%) |
After combination of Etoricoxib and Thiocolchicoside we observed that Etoricoxib is selective inhibitor of COX-2 that decreases GI toxicity and is without effects on platelet function. Thiocolchicoside, is a muscle relaxant, which has been claimed to possess GABA (gamma-Aminobutyric acid) mimetic and glycinergic actions. It is used in the symptomatic treatment of painful muscle spasm.
It has been demonstrated by recent studies concomitant administration of an Etoricoxib and Thiocolchicoside shows significantly better symptoms relief compared with the modest improvement of inflammation with each of the treatment alone.
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