Diclofenac Potassium 50 mg Paracetamol 325 mg Chlorzoxazone 250 mg Tablet
It is a pain reliever prescribed to treat a wide variety of conditions. The combination of medications makes it useful for relieving inflammation, relaxing muscle, and reducing both fevers and pains. It is commonly used to patients suffering from severe headaches, arthritis, swelling or skeletal muscle injuries.
Indications and Usage:
● Soft tissue injuries with spasm and inflammation,
● Neck / shoulder / back pain,
● Tendonitis / tenosynovitis / bursitis
● Musculoskeletal disorders
Given the multiple pathways involved in body‚s perception of pain, a combination therapy is well suited for pain management. Diclofenac acts by attenuation of peripheral prostaglandin synthesis(primarily) and has marked anti-inflammatory properties. Paracetamol acts centrally and inhibits brain prostaglandin synthesis which may partly account for its well documented activity to reduce fever and to induce analgesia. Chlorzoxazone being a centrally acting muscle relaxant, relieves muscular spasms. The combination exerts a better pain control due to action on different pathways of pain.
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10x10 (Blister)
● Drowsiness, dizziness, light- headedness, malaise, or overstimulation may be noted by an occasional patient.
● Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone.
● Pregnancy & Lactation - Not recommended in pregnant and lactating women.
Diclofenac may increase the plasma concentrations of lithium, digoxin and methotrexate. It may increase the activity of anticoagulants, inhibit the activity of diuretics, enhance cyclosporine nephrotoxicity and precipitate convulsions when co-administered with quinolone derivatives. The risk of paracetamol toxicitymay be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce hepatic microsomal enzymes. Co-administration of paracetamol with rifampicin, isoniazid, chloramphenicol, antiepileptic drugs and antiviral drugs may be avoided. Metclopromide may incraese the absorption of paracetamol whereas excretion and plasma concentration may be altered when co-administered with probeneacid. The concomitant use of chlorzoxazone with alcohol or other CNS depressants may have an additive effect.
Contraindicated in patients with known hypersensitivity to any of the ingredients.
Important Notice:- The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
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