Cefixime 200 mg Ornidazole 500 mg Tablet
Cefixime Trihydrate is an orally active antibiotic with similar antibacterial spectrum and resistance to β- lactamase as third generation cephalosporins. It inhibits an enzyme transpeptidase which is responsible for bacterial cell walls synthesis.
Ornidazole is a drug that cures some protozoan infections and prophylaxis of anaerobic bacterial infections.It is an antimicrobial agent for the treatment of infections due to trichomonads, amoebae, Giardia lamblia and anaerobic bacteria.
Cefixime Trihydrate use for :
- Tonsillitis
- Pharyngitis
- Otitismedia
- Bronchitis
- Urinary tract infections
- Gonorrhea
- Infections caused by susceptible organisms
Ornidazole use for :
- Amoebiasis
- Giardiasis
- Trichomonas vaginitis
- Anaerobic bacterial infections
- Bacterial vaginosis
Rationale of Combination :
- Unique Dual Mode Of Action
- Ornidazole-Protein synthesis inhibitor
- Cefixime-Inhibits cell wall synthesis
- Acts synergetically
- Gives better patient compliance
MK Medicine is a leading pcd franchise provider, contract manufacturer and hospital supplier of WHO-GMP certified Cefixime 200 mg Ornidazole 500 mg Tablet
(10 x 10) Alu - Alu
Contraindications
Cefixime Trihydrate
- Hypersensitivity to cephalosporins
- Along with carbamazepine
- Pseudo membranous colitis
Ornidazole
- Hypersensitivity to the drug or other imidazoles
Drug Interactions
Cefixime Trihydrate
- Probenecid: Increases and prolongs the effect
- Oral Anticoagulants: Effects of anticoagulants potentiated
Ornidazole
- Potentiates effect of coumarin-type oral anticoagulants
- Prolongs the muscle-relaxant effect of vecuronium bromide
Cefixime Trihydrate
- Diarrhea & stool changes
- Rashes & allergic manifestation
- Nephrotoxicity
- Pseudo membranous colitis
- Nausea/Vomiting
- Headache/Dizziness
Ornidazole
- Abdominal pain
- Vertigo
- Nausea/Vomiting
- Fatigue/Dry mouth
- Headache
Disclaimer:To be taken only after consulting with the doctor.
Pharmacology
Cefixime Trihydrate
Mechanism of Action
Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.
Pharmacokinetics:
Absorption: Absorbed orally up to 50 % & food delays absorption.
Distribution: Widely distributed.
Metabolism: A portion of drug is metabolized in the body.
Excretion: Excreted mainly through urine.
Onset of Action for Cefixime: Within one hour.
Duration of Action for Cefixime: 18 hours.
Half Life of Cefixime: 3 hour.
Ornidazole
Mechanism of Action
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves
● Drug enters the cell by diffusion.
● Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules.
● DNA helix destabilization &strand breakage has been observed.
Pharmacokinetics:
Absorption: Well absorbed orally.
Distribution: Widely distributed.
Metabolism: Metabolized in liver by conjugation.
Excretion: Excreted in urine and small portion is excreted in bile.
Onset of Action for Ornidazole: Within 2 hours.
Duration of Action for Ornidazole: 14hours.
Half Life of Ornidazole: 12 to 14 hours.
● Special Precautions should be taken while taking Cefixime incase of Renal impairment. Also patients allergic to peniciilins should be carefull while taking cefixime. Use cautiously along with salicylates & Probenecid. Use with caution during pregnancy and old aged patients. Contraindicated during breast feeding.
● Special Precautions while taking Ornidazole in cases of ailments like Vertigo, Mental confusion and Ataxia. Use with caution in pregnancy and it is contraindicated during the First trimester of Pregnancy. Use with caution in old age patients as well as children.
Important Notice:- The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
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