Metronidazole 400 mg Tablet

Warnings for special population

Pregnancy - This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed.

Breast-feeding - This medicine is known to excreted through the breastmilk. It is used in breastfeeding women only if clearly needed. Breastfeeding should be avoided for 24 hours after single-dose maternal treatment. Monitoring of candidal infections and diarrhea is necessary.

General warnings

Blood cell count - This medicine may lower the blood cell count and may lead to leukopenia, thrombocytopenia, and bone marrow aplasia. Close monitoring of WBC count, platelets is necessary. Discontinue the treatment if any signs of low blood cell count appear.

Neurologic Toxicity - This medicine may cause neurological effects like convulsions and peripheral neuropathy. Inform the doctor if you have any neurological problems. Any symptoms of convulsions, tingling or burning sensation of hands and feet should be reported to the doctor.

Impaired liver function - This medicine may cause liver injury. The baseline of liver enzymes should be obtained before initiating the therapy. Any signs of elevation in the liver enzymes should be informed to the doctor. Discontinue the treatment until the levels reach to normal.

• Agitationsevere
• Blurred visionsevere
• Burning or tingling sensation of hands and feetsevere
• Convulsionssevere
• Fever and chillssevere
• Skin rashsevere
• Vaginal irritationsevere
• Loss of appetitesevererare
• Constipationsevererare
• Yellow colored eyes or skinsevererare
• Abdominal pain
• Dizziness
• Change in taste/ Metallic taste
• Dry mouth

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcoholmoderate

Description - Use of alcohol or products containing alcohol during nitroimidazole therapy may result in a disulfiram-like reaction in some patients. There have been a few case reports involving metronidazole but data are not convincing. The proposed mechanism is metronidazole inhibition of aldehyde dehydrogenase (ALDH) similar to disulfiram.

Instructions - Consumption of alcohol is not recommended in patients with Metronidazole 400 MG Tablet. Any symptoms of the fast heartbeat, warmth, headache, and breathing difficulty should be reported to the doctor.