Cefpodoxime Proxetil IP 100 mg Tablet

• Before therapy with Cefpodoxime is instituted, careful inquiry should be made to determine whether patient has previously hypersensitivity reactions to Cefpodoxime, other cephalosporins, penicillin or other drugs.
• If Cefpodoxime is to be administered to penicillin sensitive patients, caution should be exercised because cross-hypersensitivity among β-lactam antibiotics has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. If an allergic reaction to Cefpodoxime occurs, discontinue use.
• Serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures, including oxygen, IV fluids, antihistamines, and airway management, as clinically indicated.
• Pseudo-membranous colitis has been reported with nearly all antibacterial agents, including Cefpodoxime and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to administration of antibacterial agents.
• Pregnancy & Lactation: Only if needed.
• Use in children: Safety and efficacy in infants.

• In case of known allergy to Cefpodoxime or to any of the antibiotics in the Cephalosporin group.
• Diarrhea
• Nausea
• Vaginal fungal infections
• Abdominal pain
• Rash
• Headache
• Vomiting

This is Prefered Dosage:
Cefpodoxime Proxetil Tablets should be administered orally with food to enhance absorption.

Disclaimer:To be taken only after consulting with the doctor.

Mechanism of Action

Cefpodoxime proxetil is a semi-synthetic beta-lactam antibiotic belonging to the third generation oral cephalosporin group. Cefpodoxime proxetil is the prodrug of the bactericidal antibiotic cefpodoxime. The antibacterial action of cefpodoxime is through inhibition of bacterial cell wall synthesis probably by acylation of membrane bound transpeptidase enzymes; this prevents cross linkage of peptidoglycan chains, which is necessary for bacterial cell wall strength and rigidity.

Pharmacokinetics

Absorption:Cefpodoxime proxetil is absorbed orally and rapidly hydrolysed by non-specific esterases in the gastro-intestinal wall to cefpodoxime, the active acid. Absorption is decreased in conditions of low gastric acidity. With cefpodoxime proxetil tablets the time taken to reach the maximum concentration (Tmax) is about 2-7 hours.
Distribution: The drug diffuses well into respiratory tissues. About 27% of cefpodoxime in the plasma is bound to plasma proteins. The volume of distribution is about 0.46 L/kg.
Metabolism: The serum half-life is about 2, 4, 6 hours.
Excretion: Clearance is around 2-4 mL/min/kg. About 81% of unchanged cefpodoxime is excreted in the urine.

• Concomitant administration of high doses of antacids (sodium bicarbonate and aluminium hydroxide) or H₂- blockers reduces peak plasma levels by 24-42 % and the extent of absorption by 27-32%, respectively.
• As with other β-lactam antibiotics, renal excretion of Cefpodoxime was inhibited by probenecid, and resulted in an approximately 31% increase in AUC and 20% increase in peak Cefpodoxime plasma levels.

• Take this medicine by mouth with a full glass of water. Take with food.
• Take your medicine at regular intervals. Do not take more often than directed.
• Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.
• Talk to your pediatrician regarding use of this medicine in children. Special care may be needed.
• Over-dosage: In the event of serious toxic reaction from over-dosage, haemodialysis or peritoneal dialysis may aid in the removal of Cefpodoxime from the body, particularly if renal function is compromised.

Cefpodoxime Proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class. The chemical name is (RS)-1(isopropoxycarbonyloxy) ethyl (+)-(6R, 7R)-7-[2-(2-amino-4-thiazolyl)-2-{(Z)methoxyimino} acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylate.