Cefixime Trihydrate IP 200 mg Clavulanic acid 125 mg Tablet

• Caution should be exercised in patients with history of diarrhea, stomach or bowel problems (eg, inflammation), bleeding or blood clotting problems, kidney or liver problems, poor nutrition, any allergy, who are taking other medications, children, during pregnancy and breast feeding.
• It may cause dizziness, do not drive a car or operate machinery while taking this medication.
• Avoid alcohol consumption.
• Avoid changing dose forms (eg, tablets, suspension) without your doctor‚s advice.
• Take full course of treatment.

Other Precautions:
• It may reduce platelet counts, avoid injury or bruising.
• Avoid any vaccination during the treatment.

• Diarrhea
• Nausea
• Vomiting
• Skin rash

Mechanism of Action

This is a semisynthetic (partially manmade), oral antibiotic in the cephalosporin family of antibiotics and it stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together so without a cell wall bacteria cannot survive and die and Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. Clavulanic acid is an irreversible inhibitor of intracellular and extracellular Beta-lactamases, demonstrating concentration-dependent and competitive inhibition.

Cefixime

Mechanism of Action

Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.

Pharmacokinetics

Absorption: Absorbed orally up to 50 % & food delays absorption.
Distribution: widely distributed.
Metabolism: A portion of drug is metabolized in the body.
Excretion: Excreted mainly through urine.
Onset of Action for Cefixime: Within one hour.
Duration of Action for Cefixime: 18 hours.
Half Life of Cefixime: 3 hour.

Clavulanic acid

Mechanism of Action

This is a semisynthetic (partially manmade), oral antibiotic in the cephalosporin family of antibiotics and it stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together so without a cell wall bacteria cannot survive and die and Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. Clavulanic acid is an irreversible inhibitor of intracellular and extracellular Beta-lactamases, demonstrating concentration-dependent and competitive inhibition.